Semnan University Press Journal of Modeling and Simulation in Electrical and Electronics Engineering 2821-0786 1 4 2022 02 01 Ion-Sensitive Field-Effect Transistor-Based Biosensor for PSA Antigen Concentration Measurement Using Microfluidic System 33 36 6879 10.22075/mseee.2022.25133.1084 EN Amir Azadi Electrical and Computer Engineering Faculty, Semnan University, Semnan, Iran Saeed Mohammadi Electrical and Computer Engineering Faculty, Semnan University, Semnan, Iran Parviz Keshavarzi Electrical and Computer Engineering Faculty, Semnan University, Semnan, Iran Journal Article 2021 11 04 Prostate cancer is one of the most common cancers in men. Prostate-Specific Antigen (PSA) is an important biomarker in the diagnosis of prostate cancer. In the present paper, an Ion-Sensitive Field-Effect Transistor (ISFET) is introduced, employing microfluidic technology to detect PSA antigens efficiently. PSA antigen is our analyte in this sensor. Due to the PSA antigen's acidity and sensor sensitivity to the hydrogen ions and pH index, absorbing the hydrogen ion by the OH receptor on the sensor surface modulates the drive current and the device's threshold voltage. The electroosmotic flow is induced inside the microchannel by applying a voltage to the electrodes on the walls of the microchannel. Consequently, turbulence in the fluid flow in the channel has occurred that effectively moves the intended analytes toward the sensor surface. The biosensor performance is investigated by the simulations carried on in COMSOL. Our simulation results indicate that the proposed structure facilitates rapid detection and measurement of PSA concentration. https://mseee.semnan.ac.ir/article_6879_c682b00967c54ccb222d4c3d13fb1a46.pdf